Furthermore, we tested the significance of these differences while controlling for confounders, such as acquisition system, age and medications. We then used those differences to classify whether an EEG is likely to have been recorded from a person with drug-resistant focal epilepsy, and if so, the epileptogenic hemisphere. We analysed the extracted features for (i) the extent to which people with drug-resistant focal epilepsy differed from healthy subjects, and (ii) whether differences within the drug-resistant focal epilepsy patients were related to the hemisphere generating seizures. After preprocessing, using a bipolar montage of eight channels, we extracted the fraction of spectral power in the alpha band (8–13 Hz) relative to a wide band of 0.5–40 Hz within 10-s windows. We analysed awake scalp EEG recordings of age-matched groups of 144 healthy individuals and 48 individuals with drug-resistant focal epilepsy who had normal scalp EEGs.
Specifically, we investigated (i) whether there are indicators of abnormal brain electrophysiology in normal EEGs of epilepsy patients, and (ii) whether such abnormalities are modulated by the side of the brain generating seizures in focal epilepsy. Here, we investigated whether normal EEGs might contain subtle electrophysiological clues of epilepsy.
However, a normal scalp EEG (based on expert visual review) recorded from a patient with epilepsy can cause delays in diagnosis and clinical care delivery. Routine scalp EEG is essential in the clinical diagnosis and management of epilepsy.
0 kommentar(er)
